Abasaglar ® (basal insulin glargine)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. Please refer to the link for full prescribing information: Abasaglar Summary of Product Characteristics (SmPC)

Are there pediatric pharmacokinetic studies for Abasaglar® (insulin glargine)?

Eli Lilly and Company has no pharmacokinetic data of Abasaglar in pediatric patients. An independent study evaluated pharmacokinetics of insulin glargine in children.

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Results from PK study with Insulin Glargine

Plasma trough concentrations of insulin glargine and its main 21A-Gly-human insulin (M1) and 21A-Gly-des-30B-Thr-human insulin (M2) metabolites

  • were similar to those observed in adult patients, and
  • provided no evidence for accumulation with chronic dosing.1,2

Patient details:

The PK study evaluated

  • 62 children
  • aged 2 to 6 years, and
  • with type 1 diabetes mellitus.1,2

References

1Danne T, Becker RHA, Ping L, Philotheou A. Insulin glargine metabolite 21A-Gly-human insulin (M1) is the principal component circulating in the plasma of young children with type 1 diabetes: results from the PRESCHOOL study. Pediatr Diabetes. 2015;16(4):299-304. https://doi.org/10.1111/pedi.12161

2Bolli GB, Hahn AD, Schmidt R, et al. Plasma exposure to insulin glargine and its metabolites M1 and M2 after subcutaneous injection of therapeutic and supratherapeutic doses of glargine in subjects with type 1 diabetes. Diabetes Care. 2012;35(12):2626-2630. https://doi.org/10.2337/dc12-0270

Date of Last Review: April 13, 2021


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