Alimta ® (pemetrexed for injection)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information.For current prescribing information for all Lilly products, including Summaries of Product Characteristics, Patient Information Leaflets and Instructions for Use, please visit: (England, Scotland, Wales) or (Northern Ireland).

Alimta (pemetrexed): Density, pH and other physical and chemical properties

Relevant physical and chemical characteristics of Alimta are provided, including osmolality, density, pH, and sensitivity to oxygen, moisture or light.

Product Characteristics

Alimta is a powder for concentrate for solution for infusion.1

Alimta is a white to either light yellow or green-yellow lyophilised powder.1

For precautions to be taken before handling or administering Alimta and for instructions on reconstitution and dilution of Alimta before administration, see summary of product characteristics section 6.6.1 

Further relevant characteristics of Alimta is provided in Table 1.

Table 1. Alimta Characteristics2




The osmolality of Alimta 500 mg solution reconstituted with 20 mL 0.9 % sodium chloride at 25°C is 514 mOsm/kg of water


The density of Alimta is approximately 1.02 g/mL at 25°C if Alimta is reconstituted with 0.9 % Sodium Chloride aqueous solution as directed


The pH of Alimta is between 6.6 & 7.8 when reconstituted in 0.9 % Sodium Chloride Injection


Alimta (pemetrexed disodium) degrades by oxidation. Alimta is oxygen sensitive and exposure to air will affect the stability. The manufacturing process was developed to minimize oxidative degradation by reducing exposure of pemetrexed solution to oxygen and upon completion of lyophilization cycle the vacuum is neutralized with sterile filtered nitrogen thus controlling the oxygen level in the drug product vial headspace.


Moisture does not impact the stability of intact vials of Alimta.  (The lyophilized powder in the intact vials of Alimta contains residual moisture).

Light sensitivity

Alimta is not sensitive to light exposure.


1. Alimta [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands

2. Data on file, Eli Lilly and Company and/or one of its subsidiaries.

Date of Last Review: 20 May 2021

Contact Lilly

Call or Email us

If you want to ask a Medical Information question or you want to report an adverse event or product complaint you can call us or email us at

Available Mon - Fri, 10am - 4pm, excluding Bank Holidays

Or you can

Chat with Us

Click to Chat is Offline

If you have a question, you can chat online with a Lilly Medical Information professional.

Submit a request