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Alimta ® (pemetrexed for injection)
This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. Please refer to the link for full prescribing information:
Alimta Summary of Product Characteristics (SmPC)
Alimta (pemetrexed): Density, pH and other physical and chemical properties
Relevant physical and chemical characteristics of Alimta are provided, including osmolality, density, pH, and sensitivity to oxygen, moisture or light.
Product
Characteristics
Alimta
is a powder for concentrate for solution for infusion.1
Alimta
is a white to either light yellow or green-yellow lyophilised
powder.1
For
precautions to be taken before handling or administering Alimta and
for instructions on reconstitution and dilution of Alimta before
administration, see summary of product characteristics section 6.6.1
Further
relevant characteristics of Alimta is provided in Table
1.
The
osmolality of Alimta 500 mg solution reconstituted with 20 mL
0.9 % sodium chloride at 25°C is 514 mOsm/kg of
water
Density
The
density of Alimta is approximately 1.02 g/mL at 25°C if
Alimta is reconstituted with 0.9 % Sodium Chloride aqueous
solution as directed
pH
The
pH of Alimta is between 6.6 & 7.8 when reconstituted in 0.9 %
Sodium Chloride Injection
Oxygen
Alimta
(pemetrexed disodium) degrades by oxidation. Alimta is oxygen
sensitive and exposure to air will affect the stability. The
manufacturing process was developed to minimize oxidative
degradation by reducing exposure of pemetrexed solution to oxygen
and upon completion of lyophilization cycle the vacuum is
neutralized with sterile filtered nitrogen thus controlling the
oxygen level in the drug product vial headspace.
Moisture
Moisture
does not impact the stability of intact vials of Alimta.
(The lyophilized powder in the intact vials of Alimta contains
residual moisture).
Light
sensitivity
Alimta
is not sensitive to light exposure.
References
1.
Alimta [summary of product characteristics]. Eli Lilly Nederland
B.V., The Netherlands
2.
Data on file, Eli Lilly and Company and/or one of its subsidiaries.
Date of Last Review:May 20, 2021
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