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Alimta ® (pemetrexed for injection)
This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. Please refer to the link for full prescribing information:
Alimta Summary of Product Characteristics (SmPC)
Alimta (pemetrexed): Density, pH and other physical and chemical properties
Relevant physical and chemical characteristics of Alimta are provided, including osmolality, density, pH, and sensitivity to oxygen, moisture or light.
is a powder for concentrate for solution for infusion.1
is a white to either light yellow or green-yellow lyophilised
precautions to be taken before handling or administering Alimta and
for instructions on reconstitution and dilution of Alimta before
administration, see summary of product characteristics section 6.6.1
relevant characteristics of Alimta is provided in Table
osmolality of Alimta 500 mg solution reconstituted with 20 mL
0.9 % sodium chloride at 25°C is 514 mOsm/kg of
density of Alimta is approximately 1.02 g/mL at 25°C if
Alimta is reconstituted with 0.9 % Sodium Chloride aqueous
solution as directed
pH of Alimta is between 6.6 & 7.8 when reconstituted in 0.9 %
Sodium Chloride Injection
(pemetrexed disodium) degrades by oxidation. Alimta is oxygen
sensitive and exposure to air will affect the stability. The
manufacturing process was developed to minimize oxidative
degradation by reducing exposure of pemetrexed solution to oxygen
and upon completion of lyophilization cycle the vacuum is
neutralized with sterile filtered nitrogen thus controlling the
oxygen level in the drug product vial headspace.
does not impact the stability of intact vials of Alimta.
(The lyophilized powder in the intact vials of Alimta contains
is not sensitive to light exposure.
Alimta [summary of product characteristics]. Eli Lilly Nederland
B.V., The Netherlands
Data on file, Eli Lilly and Company and/or one of its subsidiaries.
Date of Last Review:May 20, 2021
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