Abasaglar ® (basal insulin glargine)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. Please refer to the link for full prescribing information: Abasaglar Summary of Product Characteristics (SmPC)

Abasaglar® (insulin glargine): Use in Hepatic Impairment

The effect of hepatic impairment on the pharmacokinetics of Abasaglar has not been studied.

Detailed Information

The effect of hepatic impairment on the PK of Abasaglar has not been studied.1

In patients with hepatic impairment, insulin requirements may be diminished due to reduced capacity for gluconeogenesis and reduced insulin metabolism.2

As with all insulin products, more frequent glucose monitoring and dosage adjustment may be necessary for Abasaglar in patients with hepatic impairment. Patients with hepatic impairment may be at higher risk for hypoglycemia.1

Some studies with human insulin have shown increased circulating levels of insulin in patients with hepatic failure.1

References

1. Data on file, Eli Lilly and Company and/or one of its subsidiaries.

2. Abasaglar [summary of product characteristics]. Eli Lilly Nederland B.V., The Netherlands.

Glossary

Abasaglar = Abasaglar® (insulin glargine) 100 units/mL

PK = pharmacokinetic

Date of Last Review: April 02, 2019

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