Abasaglar ® (basal insulin glargine)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. Please refer to the link for full prescribing information: Abasaglar Summary of Product Characteristics (SmPC)

Abasaglar® (insulin glargine): Onset of action

The median onset of action for Abasaglar is approximately 1 to 2 hours.

Detailed Information

A total of 3 single-site, randomized, double-blind, 2-treatment, 4-period, crossover, euglycemic clamp studies were conducted in healthy subjects to evaluate similarity in the PK and PD of

  • Abasaglar

  • the US-approved version of Lantus, and

  • the EU-approved version of Lantus.1

The median onset of action, defined as the time of first change of glucose infusion rate postdose, was similar between study groups and ranged from

  • 0.81 to 2.10 hours for Abasaglar

  • 1.70 to 1.87 hours for the US-approved version of Lantus, and

  • 0.83 to 2.13 hours for the EU-approved version of Lantus.1

The onset of action for Abasalar

  • varies with dose and among patient populations, and

  • is expected to be shorter for patients with DM compared with healthy subjects.2


1. Linnebjerg H, Lam ECQ, Seger ME, et al. Comparison of the pharmacokinetics and pharmacodynamics of LY2963016 insulin glargine and EU- and US-approved versions of Lantus insulin glargine in healthy subjects: three randomized euglycemic clamp studies. Diabetes Care. 2015;38(12):2226-2233. http://dx.doi.org/10.2337/dc14-2623

2. Data on file, Eli Lilly and Company and/or one of its subsidiaries.


Abasaglar = Abasaglar® (insulin glargine) 100 units/mL

DM = diabetes mellitus

EU = European Union

Lantus = Lantus® (insulin glargine) 100 units/mL

PD = pharmacodynamic

PK = pharmacokinetic  

US = United States

Date of Last Review: October 07, 2019

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