Abasaglar ® (basal insulin glargine)

This information is intended for UK registered healthcare professionals only as a scientific exchange in response to your search for information. Please refer to the link for full prescribing information: Abasaglar Summary of Product Characteristics (SmPC)

Abasaglar® (insulin glargine) : Half-Life

The half-life of Abasaglar was calculated from clinical study data and is approximately 10 hours.

Detailed Information

A total of 3 single-site, randomized, double-blind, 2-treatment, 4-period, crossover, euglycemic clamp studies were conducted in healthy subjects to evaluate similarity in the PK and PD of

  • Abasaglar

  • the US-approved version of Lantus, and

  • the EU-approved version of Lantus.1

The PK parameter estimates, including half-life, were calculated and demonstrated similarity between Abasaglar and Lantus (Table 1. Calculated Half-Life for Abasaglar and Lantus After a Single Subcutaneous Dose ).1

Table 1. Calculated Half-Life for Abasaglar and Lantus After a Single Subcutaneous Dose1


Study Drug 
(0.5 units/kg)

Geometric Mean (CV%)


Half-lifea, h


10.0 (59)


US-approved Lantus

11.6 (69)



9.95 (66)


EU-approved Lantus

9.76 (61)


Abbreviations: Abasaglar = Abasaglar® (insulin glargine) 100 units/mL; CV = coefficient of variation; US-approved/EU-approved Lantus = United States-approved/European Union-approved Lantus® (insulin glargine) 100 units/mL.

a Half-life associated with the terminal rate constant.


1. Linnebjerg H, Lam EC, Seger ME, et al. Comparison of the pharmacokinetics and pharmacodynamics of LY2963016 insulin glargine and EU- and US-approved versions of Lantus insulin glargine in healthy subjects: three randomized euglycemic clamp studies. Diabetes Care. 2015;38(12):2226-2233. http://dx.doi.org/10.2337/dc14-2623


Abasaglar = Abasaglar® (insulin glargine) 100 units/mL

EU = European Union

Lantus = Lantus® (insulin glargine) 100 units/mL

PD = pharmacodynamic

PK = pharmacokinetic

Date of Last Review: July 24, 2019

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